Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis

Publication Details

Authors: DA Barr, JM Lewis, N Feasey, C Schutz, JK Varma, et al.

Year: 2020

Source: The Lancet Infectious Diseases

Publisher: thelancet.com

Citations: 81

Citations per Year: 16.2

Google Scholar Rank: 3

Author Count: 5

Abstract

Background: The clinical and epidemiological significance of HIV-associated Mycobacterium tuberculosis bloodstream infection (BSI) is incompletely understood. We hypothesised that M tuberculosis BSI represents a distinct clinical entity with specific risk factors, diagnostic challenges, and mortality outcomes in seriously ill adults with HIV infection. This comprehensive systematic review and meta-analysis examines the prevalence, diagnosis, and mortality risk associated with M tuberculosis bloodstream infections in seriously ill HIV-positive adults, providing critical evidence for clinical management, diagnostic strategies, and treatment protocols in this vulnerable patient population with high mortality risk.

Key Findings

• M tuberculosis bloodstream infection prevalence and clinical significance in HIV patients
• Diagnostic challenges and detection methods for TB BSI in seriously ill adults
• Mortality risk assessment and clinical outcome predictors
• Risk factor identification and patient population characteristics
• Evidence-based clinical management and treatment protocol recommendations

Research Impact

This important systematic review and meta-analysis (81 citations) provided critical evidence on Mycobacterium tuberculosis bloodstream infections in HIV patients, informing clinical practice guidelines, diagnostic strategies, and treatment protocols for managing this high-mortality condition in seriously ill HIV-positive adults worldwide.

Publication Access

Full Text: The Lancet Infectious Diseases

Citation Information: Google Scholar Citations